Get ready for this one is a long one!
With high enough dodging skill, you won't need to worry much about getting hit by hulk fists. I'm level 10 in the skill right now and the game keeps saying that I can't earn any more xp by dodging hulk mega-punches
Of course my level 10 skill is diminished from the stuff I'm wearing, but I'm still pretty good!
In terms of dangerous situations, (I think I posted one before), I don't really run into 'dangerous' situations much lately. Once you get to the point where there is like a 10% chance (if even that) of actually getting hit in melee, armor that stops (seemingly) every hit, you stay inside towns instead of risking turrets and other crazy stuff elsewhere, acid zombies are off, you have potential meat-shield friends, it isn't usually too bad.
Honestly, the reason I don't go into other places other than my town isn't because I'm a wimp, it's just that my town is HUGE! And getting to anywhere else will take annoyingly long, plus my computer can't handle speed moving in a direction. Even if it could my followers are usually slower than me.
I suppose there is also the fact that I also basicly do less damage with a freaking sword that with my fists. I'm literally a bionic mutant that punches things to death simply for fun. Shocker hulk? *punches five or four times* New bionics? Yay!
I have Muay Thai with 27 strength. melee damage without Mauy thai is 20.3, but that fighting type makes it so the higher the strength, the more the damage! And i have nail nuckles which add more damage than fists but allow Muay Thai. So I can deal like 30 damage and usually one shot dog types, among other things. I actually bumped up the resillience on monsters by like 20% also.
It might not be the 'most' dangerous situation, but picking a fight with me would be a very bad idea... Well, bullets are potentially dangerous, but I have pretty good armor and 162 base health. now that I think about it, I'm kinda tempted to get shot simply to see how much 'damage' it does!